-
Key learnings from real-world data are applied as Takeda continues to
evolve its hematology portfolio, advancing treatment for the bleeding
disorders community
- Pre-clinical scientific studies demonstrate potential opportunities to improve upon adeno-associated virus gene therapies for hemophilia and other monogenic diseases
Contacts
Japanese Media
Kazumi Kobayashi
kazumi.kobayashi@takeda.com
+81 (0) 3-3278-2095
Media outside Japan
David Murdoch
david.murdoch@takeda.com
+1 781-421-1741
- Pre-clinical scientific studies demonstrate potential opportunities to improve upon adeno-associated virus gene therapies for hemophilia and other monogenic diseases
OSAKA, Japan-Wednesday 11 December 2019 [ AETOS Wire ]
Takeda also presented data from preclinical scientific studies regarding certain known limitations of AAV gene therapies. These studies will inform Takeda's approach to its own investigational AAV gene therapy programs; TAK-754, an investigational AAV gene therapy for hemophilia A is currently in Phase 1 clinical study, soon to be followed by other potential gene therapies including TAK-748, an investigational gene therapy for hemophilia B.
ADYNOVATE is a human antihemophilic factor indicated in children and adults with hemophilia A (congenital factor VIII deficiency) for:
Prior anaphylactic reaction to ADYNOVATE, to the parent molecule (ADVATE [Antihemophilic Factor (Recombinant)]), mouse or hamster protein, or excipients of ADYNOVATE (e.g. Tris, mannitol, trehalose, glutathione, and/or polysorbate 80).
Hypersensitivity Reactions
Hypersensitivity reactions are possible with ADYNOVATE. Allergic-type hypersensitivity reactions, including anaphylaxis, have been reported with other recombinant antihemophilic factor VIII products, including the parent molecule, ADVATE. Early signs of hypersensitivity reactions that can progress to anaphylaxis may include angioedema, chest tightness, dyspnea, wheezing, urticaria, and pruritus. Immediately discontinue administration and initiate appropriate treatment if hypersensitivity reactions occur.
Hemophilia is a challenging chronic disease that causes longer-than-normal bleeding due to absent or deficient clotting factor in the blood.7 Hemophilia A is more common than hemophilia B;7 hemophilia A affects about 158,225 people, whereas hemophilia B affects about 31,247 people worldwide.8
Following its recent acquisition of Shire, Takeda is a leader in hemophilia with the longest heritage and market-leading portfolio, backed by established safety and efficacy profiles with decades of real-world experience. We have 70+ years driving innovation for patients9 and a broad portfolio of 11 products across multiple bleeding disorders.10 Our experience as leaders in hematology means we are well prepared to meet today’s needs as we pursue future developments in the care of bleeding disorders. Together with the hematology community, we are raising expectations for the future, including earlier diagnosis, earlier and full protection against bleeds, and more personalized patient care.
Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to bringing Better Health and a Brighter Future to patients by translating science into highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Gastroenterology (GI), Neuroscience and Rare Diseases. We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.
(BUSINESS WIRE)-- Takeda Pharmaceutical Company Limited (TSE: 4502/NYSE:TAK) (“Takeda”), today presented nine hematology poster presentations at the 61st American
Society of Hematology (ASH) Annual Meeting that underscore its
commitment to advancing treatments for rare bleeding disorders by
incorporating real-world data and developing innovative adeno-associated
virus (AAV) gene therapies.
Understanding Real-World Evidence to Advance Patient-Centric Innovation in Bleeding Disorders
Real-world
evidence from studies across many of Takeda’s portfolio of treatments
for hemophilia demonstrate the cost savings and patient benefits
resulting from ongoing personalized treatment. However, in von
Willebrand disease, real-world evidence highlights the ongoing unmet
clinical need for personalization, as it may enable improved treatment
outcomes. Insights presented at ASH include:
- ADYNOVATE ® [Antihemophilic Factor (Recombinant), PEGylated]: In the poster “Real-World Age-Stratified FVIII Consumption and Bleed Outcomes Before and After Switching to Rurioctocog Alfa Pegol in a Retrospective, Observational Study Using US Specialty Pharmacy Data,” (abstract 2411) outcomes found those who switched experienced a significant 40-50% decrease in their annualized bleed rate.
- Hemophilia A: In the poster “Cost-Effectiveness Model of Recombinant FVIII Versus Emicizumab Treatment of Patients With Severe Hemophilia A Without Inhibitors,” (abstract 2102) results found that prophylaxis with rFVIII was estimated to be less costly and more effective over an estimated 70-year lifespan of a patient with severe hemophilia A.
- FEIBA® [Anti-Inhibitor Coagulant Complex]: The poster “Real-World Clinical Management of Patients with Hemophilia and Inhibitors: Effectiveness and Safety of aPCC in Patients with >18 Months’ Follow-up in the FEIBA Global Outcome Study (FEIBA GO)” (abstract 2418) describes the long-term, real-world safety and efficacy of FEIBA in patients with congenital hemophilia A or B with inhibitors across different clinical settings.
- Von Willebrand Disease: Data
from two studies that aim to advance scientific knowledge and
understanding of von Willebrand disease (VWD), including the following
retrospective analyses:
- The poster “Analysis of Bleeding and Treatment Patterns in Children and Adolescents before and after von Willebrand Disease Diagnosis Using Data from a US Medical Claims Database” (abstract 2117) highlights U.S. medical claims data that characterizes the diagnosis, bleeding and treatment patterns in children and adolescents with VWD and points to the need for improved treatment and care of this patient population.
- Additionally, the poster “Estimation of the Economic Burden Associated with Major Surgery Due to von Willebrand Disease Based on Claims Data from the USA” (abstract 4692) assesses the economic burden associated with major surgeries in patients with VWD and found that these patients incur significantly higher costs for health care resources compared to patients without VWD who had similar types of surgery.
“Real-world
evidence plays a crucial role in understanding patterns of care that
happen in day-to-day medical practice outside of rigorous clinical
studies,” said Jonathan Roberts, MD, Associate Medical Director,
Bleeding & Clotting Disorders Institute, Peoria, Ill. “The U.S.
medical claims data show improvement is needed around management of von
Willebrand disease in children and adolescents to optimize treatment and
reduce the amount of bleeding episodes following diagnosis.”
Preclinical Scientific Studies Address Challenges of Current AAV Gene Therapies
Takeda also presented data from preclinical scientific studies regarding certain known limitations of AAV gene therapies. These studies will inform Takeda's approach to its own investigational AAV gene therapy programs; TAK-754, an investigational AAV gene therapy for hemophilia A is currently in Phase 1 clinical study, soon to be followed by other potential gene therapies including TAK-748, an investigational gene therapy for hemophilia B.
The
treatment goal of gene therapy for hemophilia is to provide sustained
therapeutic levels of endogenous clotting factor over multiple years.
Hemophilia gene therapies have the potential to provide prolonged,
high-level expression of factor, and limit the need for frequent factor
infusion.1,2 To deliver gene therapy to a patient, a normal copy of a missing gene is packaged into a delivery vehicle, called a vector.3 Recombinant
AAV, particularly those delivered by AAV5 and AAV8 capsid serotypes,
serve as the vector in most of the ongoing hemophilia studies.3 The vector delivers the functional gene into a patient’s liver cells, which can then properly produce blood-clotting proteins. 4,5 However,
patients’ pre-existing immunity to AAV8 capsid, and other AAV
serotypes, can impact the safety and efficacy of these therapies.3
To
better understand the prevalence of pre-existing immunity against
commonly used AAV2, AAV5 and AAV8 capsid in adult patients with
hemophilia, Takeda conducted an international prospective and ongoing
epidemiological study, “Co-Prevalence of Pre-Existing Immunity to
Different Serotypes of Adeno-Associated Virus (AAV) in Adults with
Hemophilia,” (abstract 3349)
that found 50% of patients with hemophilia have neutralizing antibodies
to AAV2, AAV5 or AAV8 capsid with 40% demonstrating co-prevalence to
all three evaluated serotypes. As a result, these patients are not
likely to respond to gene therapies based on AAV vectors.3
“As
we continue to advance our hemophilia A and hemophilia B
investigational gene therapy programs, Takeda is also investigating
approaches to overcome the challenges of current AAV gene therapies that
could potentially be applied to hemophilia and other rare monogenic
diseases,” said Dan Curran, M.D., Head, Rare Diseases Therapeutic Area
Unit at Takeda. “Developing new gene therapy approaches – including
those capable of treating pre-existing immunity to AAV, enabling
re-dosing, lowering doses, enhancing biodistribution and developing
alternative gene delivery vehicles – are critical to one day providing
functional cures to patients.”
The
poster “AAV8-Specific Immune Adsorption Column: A Treatment Option for
Patients with Pre-Existing Anti-AAV8 Neutralizing Antibodies,” (abstract 5922) reported pre-clinical data on one potential approach to overcoming pre-existing AAV immunity.6 In the study, an AAV8-specific immune adsorption column (IAC) was used to mimic the processing of patients’ plasma in an in vitro setting by applying different treatment cycles to plasma reservoirs which shows anti-AAV8 titers could be depleted.6 Insights
from this study will be applied to Takeda’s research to determine if an
IAC could enable the administration of AAV8 gene therapies to patients
with pre-existing immunity and potentially facilitate the
re-administration of gene therapy.6
ADYNOVATE Professional Important Information
ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] Important Information
Indications and Limitation of Use
ADYNOVATE is a human antihemophilic factor indicated in children and adults with hemophilia A (congenital factor VIII deficiency) for:
- On-demand treatment and control of bleeding episodes
- Perioperative management
- Routine prophylaxis to reduce the frequency of bleeding episodes
ADYNOVATE is not indicated for the treatment of von Willebrand disease.
DETAILED IMPORTANT RISK INFORMATION
CONTRAINDICATIONS
Prior anaphylactic reaction to ADYNOVATE, to the parent molecule (ADVATE [Antihemophilic Factor (Recombinant)]), mouse or hamster protein, or excipients of ADYNOVATE (e.g. Tris, mannitol, trehalose, glutathione, and/or polysorbate 80).
WARNINGS & PRECAUTIONS
Hypersensitivity Reactions
Hypersensitivity reactions are possible with ADYNOVATE. Allergic-type hypersensitivity reactions, including anaphylaxis, have been reported with other recombinant antihemophilic factor VIII products, including the parent molecule, ADVATE. Early signs of hypersensitivity reactions that can progress to anaphylaxis may include angioedema, chest tightness, dyspnea, wheezing, urticaria, and pruritus. Immediately discontinue administration and initiate appropriate treatment if hypersensitivity reactions occur.
Neutralizing Antibodies
Formation of neutralizing antibodies (inhibitors) to factor VIII can occur following administration of ADYNOVATE. Monitor patients regularly for the development of factor VIII inhibitors by appropriate clinical observations and laboratory tests. Perform an assay that measures factor VIII inhibitor concentration if the plasma factor VIII level fails to increase as expected, or if bleeding is not controlled with expected dose.
Formation of neutralizing antibodies (inhibitors) to factor VIII can occur following administration of ADYNOVATE. Monitor patients regularly for the development of factor VIII inhibitors by appropriate clinical observations and laboratory tests. Perform an assay that measures factor VIII inhibitor concentration if the plasma factor VIII level fails to increase as expected, or if bleeding is not controlled with expected dose.
ADVERSE REACTIONS
The most common adverse reactions (≥1% of subjects) reported in the clinical studies were headache and nausea.
The most common adverse reactions (≥1% of subjects) reported in the clinical studies were headache and nausea.
Click here for Full Prescribing Information https://www.shirecontent.com/PI/PDFs/ADYNOVATE_USA_ENG.pdf
FEIBA [Anti-Inhibitor Coagulant Complex] Indications and Detailed Important Risk Information
Indications for FEIBA
FEIBA is an Anti-Inhibitor Coagulant Complex indicated for use in hemophilia A and B patients with inhibitors for:
- Control and prevention of bleeding episodes
- Perioperative management
- Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.
FEIBA
is not indicated for the treatment of bleeding episodes resulting from
coagulation factor deficiencies in the absence of inhibitors to
coagulation factor VIII or coagulation factor IX.
Detailed Important Risk Information for FEIBA
WARNING: EMBOLIC AND THROMBOTIC EVENTS
- Thromboembolic events have been reported during post-marketing surveillance following infusion of FEIBA, particularly following the administration of high doses (above 200 units per kg per day) and/or in patients with thrombotic risk factors.
- Monitor patients receiving FEIBA for signs and symptoms of thromboembolic events.
CONTRAINDICATIONS
FEIBA is contraindicated in patients with:
- History of anaphylactic or severe hypersensitivity reactions to FEIBA or any of its components, including factors of the kinin generating system
- Disseminated intravascular coagulation (DIC)
- Acute thrombosis or embolism (including myocardial infarction)
WARNINGS AND PRECAUTIONS
Thromboembolic
events (including venous thrombosis, pulmonary embolism, myocardial
infarction, and stroke) can occur, particularly following the
administration of high doses (>200 units/kg/day) and/or in patients
with thrombotic risk factors.
Patients
with DIC, advanced atherosclerotic disease, crush injury, septicemia,
or concomitant treatment with recombinant factor VIIa have an increased
risk of developing thrombotic events due to circulating tissue factor or
predisposing coagulopathy. Potential benefit of treatment should be
weighed against potential risk of these thromboembolic events.
Infusion
should not exceed a single dose of 100 units/kg and daily doses of 200
units/kg. Maximum injection or infusion rate must not exceed 2
units/kg/minute. Monitor patients receiving >100 units/kg for the
development of DIC, acute coronary ischemia and signs and symptoms of
other thromboembolic events. If clinical signs or symptoms occur, such
as chest pain or pressure, shortness of breath, altered consciousness,
vision, or speech, limb or abdomen swelling and/or pain, discontinue
FEIBA and initiate appropriate diagnostic and therapeutic measures.
Safety
and efficacy of FEIBA for breakthrough bleeding in patients receiving
emicizumab has not been established. Cases of thrombotic microangiopathy
(TMA) were reported in a clinical trial where subjects received FEIBA
as part of a treatment regimen for breakthrough bleeding following
emicizumab treatment. Consider the benefits and risks with FEIBA if
considered required for patients receiving emicizumab prophylaxis. If
treatment with FEIBA is required for patients receiving emicizumab, the
hemophilia treating physician should closely monitor for signs and
symptoms of TMA. In FEIBA clinical studies TMA has not been reported.
Hypersensitivity
and allergic reactions, including severe anaphylactoid reactions, can
occur. Symptoms include urticaria, angioedema, gastrointestinal
manifestations, bronchospasm, and hypotension. Reactions can be severe
and systemic (e.g., anaphylaxis with urticaria and angioedema,
bronchospasm, and circulatory shock). Other infusion reactions, such as
chills, pyrexia, and hypertension have also been reported. If signs and
symptoms of severe allergic reactions occur, immediately discontinue
FEIBA and provide appropriate supportive care.
Because
FEIBA is made from human plasma it may carry a risk of transmitting
infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease
(vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD)
agent.
FEIBA
contains blood group isohemagglutinins (anti-A and anti-B). Passive
transmission of antibodies to erythrocyte antigens, e.g., A, B, D, may
interfere with some serological tests for red cell antibodies, such as
antiglobulin test (Coombs test).
ADVERSE REACTIONS
Most
frequently reported adverse reactions observed in >5% of subjects in
the prophylaxis trial were anemia, diarrhea, hemarthrosis, hepatitis B
surface antibody positive, nausea, and vomiting.
Serious
adverse reactions seen are hypersensitivity reactions and
thromboembolic events, including stroke, pulmonary embolism and deep
vein thrombosis.
DRUG INTERACTIONS
Consider
possibility of thrombotic events when systemic antifibrinolytics such
as tranexamic acid and aminocaproic acid are used with FEIBA. No
adequate and well-controlled studies of combined or sequential use of
FEIBA and recombinant factor VIIa, antifibrinolytics, or emicizumab,
have been conducted. Use of antifibrinolytics within approximately 6 to
12 hours after FEIBA is not recommended.
Clinical experience from an emicizumab clinical trial suggests that a potential drug interaction may exist with emicizumab.
About Hemophilia
Hemophilia is a challenging chronic disease that causes longer-than-normal bleeding due to absent or deficient clotting factor in the blood.7 Hemophilia A is more common than hemophilia B;7 hemophilia A affects about 158,225 people, whereas hemophilia B affects about 31,247 people worldwide.8
People
with hemophilia, working closely with their healthcare professionals,
can live healthy lives with proper care and adequate treatment.7 Treatment
regimens typically include on-demand and/or regular prophylactic
infusions of factor replacement therapy to control or prevent the risk
of bleeding.7,8
About Takeda Hematology
Following its recent acquisition of Shire, Takeda is a leader in hemophilia with the longest heritage and market-leading portfolio, backed by established safety and efficacy profiles with decades of real-world experience. We have 70+ years driving innovation for patients9 and a broad portfolio of 11 products across multiple bleeding disorders.10 Our experience as leaders in hematology means we are well prepared to meet today’s needs as we pursue future developments in the care of bleeding disorders. Together with the hematology community, we are raising expectations for the future, including earlier diagnosis, earlier and full protection against bleeds, and more personalized patient care.
About Takeda Pharmaceutical Company
Takeda Pharmaceutical Company Limited (TSE:4502/NYSE:TAK) is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to bringing Better Health and a Brighter Future to patients by translating science into highly-innovative medicines. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Gastroenterology (GI), Neuroscience and Rare Diseases. We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people's lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.
For more information, visit https://www.takeda.com.
References
1. National Hemophilia Foundation. Future Therapies. Accessible at: https://www.hemophilia.org/Bleeding-Disorders/Future-Therapies. Accessed: November 2019.
2. Wong, T. & Recht, M. Drugs (2011) 71: 305.
3. Rajavel, K et al. Co-Prevalence of Pre-Existing Immunity to Different Serotypes of Adeno-Associated Virus (AAV) in Adults with Hemophilia. Data on File.
4. Doshi BS, Arruda VR. Gene Therapy for Hemophilia: What Does the Future Hold? Therapeutic Advances in Hematology. 2018; 9(9):273-293.
5. Pipe, SW. Gene therapy for hemophilia. Pediatric Blood Cancer. 2018; 65(2): e26865.
6. Kruzik, A et al. AAV8-specific immune adsorption column: A treatment option for patients with pre- existing anti-AAV8 neutralizing antibodies. Data on File.
7. World Federation of Hemophilia. “What is hemophilia?” World Federation of Hemophilia website. http://www.wfh.org/en/page.aspx?pid=646. Last Accessed April 2019.
8. World Federation of Hemophilia. Report on the Annual Global Survey 2017. World Federation of Hemophilia website. http://www1.wfh.org/publications/files/pdf-1714. pdf Last Accessed April 2019.
9.World Federation of Hemophilia. “About Bleeding Disorders: Treatment.” World Federation of Hemophilia website. https://www.wfh.org/en/page.aspx?pid=642. Last Accessed April 2019.
10. Shire Website. Product List. Website: https://www.shire.com/products/product-list?t=. Last Accessed June 2019.
1. National Hemophilia Foundation. Future Therapies. Accessible at: https://www.hemophilia.org/Bleeding-Disorders/Future-Therapies. Accessed: November 2019.
2. Wong, T. & Recht, M. Drugs (2011) 71: 305.
3. Rajavel, K et al. Co-Prevalence of Pre-Existing Immunity to Different Serotypes of Adeno-Associated Virus (AAV) in Adults with Hemophilia. Data on File.
4. Doshi BS, Arruda VR. Gene Therapy for Hemophilia: What Does the Future Hold? Therapeutic Advances in Hematology. 2018; 9(9):273-293.
5. Pipe, SW. Gene therapy for hemophilia. Pediatric Blood Cancer. 2018; 65(2): e26865.
6. Kruzik, A et al. AAV8-specific immune adsorption column: A treatment option for patients with pre- existing anti-AAV8 neutralizing antibodies. Data on File.
7. World Federation of Hemophilia. “What is hemophilia?” World Federation of Hemophilia website. http://www.wfh.org/en/page.aspx?pid=646. Last Accessed April 2019.
8. World Federation of Hemophilia. Report on the Annual Global Survey 2017. World Federation of Hemophilia website. http://www1.wfh.org/publications/files/pdf-1714. pdf Last Accessed April 2019.
9.World Federation of Hemophilia. “About Bleeding Disorders: Treatment.” World Federation of Hemophilia website. https://www.wfh.org/en/page.aspx?pid=642. Last Accessed April 2019.
10. Shire Website. Product List. Website: https://www.shire.com/products/product-list?t=. Last Accessed June 2019.
Important Notice
For
the purposes of this notice, “press release” means this document, any
oral presentation, any question and answer session and any written or
oral material discussed or distributed by Takeda Pharmaceutical Company
Limited (“Takeda”) regarding this release. This press
release (including any oral briefing and any question-and-answer in
connection with it) is not intended to, and does not constitute,
represent or form part of any offer, invitation or solicitation of any
offer to purchase, otherwise acquire, subscribe for, exchange, sell or
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The
companies in which Takeda directly and indirectly owns investments are
separate entities. In this press release, “Takeda” is sometimes used for
convenience where references are made to Takeda and its subsidiaries in
general. Likewise, the words “we”, “us” and “our” are also used to
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press release and any materials distributed in connection with this
press release may contain forward-looking statements, beliefs or
opinions regarding Takeda’s future business, future position and results
of operations, including estimates, forecasts, targets and plans for
Takeda. In particular, this press release contains forecasts and
management estimates related to the financial and operational
performance of Takeda, including statements regarding forecasts for
Revenue, Operating profit, Adjusted EBITDA, Profit before income taxes,
Net profit attributable to owners of Takeda, Basic earnings per share,
Amortization and impairment and other income/expense, Underlying
Revenue, Underlying Core Earnings margin, Underlying Core EPS and Net
Debt. Without limitation, forward looking statements often include the
words such as “targets”, “plans”, “believes”, “hopes”, “continues”,
“expects”, “aims”, “intends”, “will”, “may”, “should”, “would”, “could”
“anticipates”, “estimates”, “projects” or words or terms of similar
substance or the negative thereof. Any forward-looking statements in
this document are based on the current assumptions and beliefs of Takeda
in light of the information currently available to it. Such
forward-looking statements do not represent any guarantee by Takeda or
its management of future performance and involve known and unknown
risks, uncertainties and other factors, including but not limited to:
the economic circumstances surrounding Takeda’s business, including
general economic conditions in Japan, the United States and worldwide;
competitive pressures and developments; applicable laws and regulations;
the success of or failure of product development programs; decisions of
regulatory authorities and the timing thereof; changes in exchange
rates; claims or concerns regarding the safety or efficacy of marketed
products or products candidates; and post-merger integration with
acquired companies, any of which may cause Takeda’s actual results,
performance, achievements or financial position to be materially
different from any future results, performance, achievements or
financial position expressed or implied by such forward-looking
statements. For more information on these and other factors which may
affect Takeda’s results, performance, achievements, or financial
position, see “Item 3. Key Information—D. Risk Factors” in Takeda’s
Registration Statement on Form 20-F filed with the
U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/reports/sec-filings/ or at www.sec.gov.
Neither Takeda nor its management gives any assurances that the
expectations expressed in these forward-looking statements will turn out
to be correct, and actual results, performance or achievements could
materially differ from expectations. Persons receiving this press
release should not place undue reliance on forward looking statements.
Takeda undertakes no obligation to update any of the forward-looking
statements contained in this press release or any other forward-looking
statements it may make. Past performance is not an indicator of future
results and the results of Takeda in this press release may not be
indicative of, and are not an estimate, forecast or projection of
Takeda’s future results.
View source version on businesswire.com: https://www.businesswire.com/news/home/20191209005481/en/
Contacts
Japanese Media
Kazumi Kobayashi
kazumi.kobayashi@takeda.com
+81 (0) 3-3278-2095
Media outside Japan
David Murdoch
david.murdoch@takeda.com
+1 781-421-1741
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